Depression: magnetic resonance spectroscopy studies (review)

Magnetic resonance spectroscopy (MRS) is a non-invasive method for assessing the neurochemical state of brain. In recent years, growth in number high-field scanners has led to rapid increase such studies and improvement quality MRS data, development mechanisms technologies obtaining processing results.The review devoted study possibilities brain neurochemistry depression. The fundamentals techniques various approaches MRS, technical requirements material, advantages disadvantages method, difficulties interpreting results, prospects combining with fMRI EEG are considered. Most spectroscopic performed depression show an abnormal decrease concentrations amino acid neurotransmitters γ-aminobutyric glutamate, which consistent results post-mortem histopathological studies. Multivariate needed determine anatomical clinical specificity changes Glx GABA levels that found depressed patients.The presented material can be used form basis further multimodal experiments using may relevant both informed more effective drugs, last but not least, neurofeedback tools aimed at interactive interventions neural network organization depressive disorders.